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P.S. You Should Know... | Issue #156

👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7
March 22 · Issue #156 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fourth year!

my story 🚀
The latest and greatest facts come at us at light speed. Anecdotes, statistics and passionate opinions seem to reproduce as virally as, well, a virus. Once we know something, we’re prone to defend that knowledge despite new information. Time shows us that we are wrong often. We have trouble realizing we’re wrong until much later. What’s the rational move? Here’s mine: Take the time to do my own thinking before forming an opinion. Allow room for doubt even after I form an opinion. Consider the facts from a wider historical (or geographic, or cultural) lens. These tactics are much harder during times of rapid change and in unfamiliar circumstances. “Only the paranoid survive” is the title of an Andy Grove book. I’m paranoid that my mental shortcuts are out to get me! I continue my effort to be less certain as the facts whiz by at light speed.
someone else's words 💬
fun facts 🙌
There are no mosquitoes at Disney World. And that’s despite the fact that it’s built on swampland, Disney manages to keep the park bug-free. | learn more
NASA fixes Mars lander by telling it to hit itself with a shovel. I’m reminded of how to fix problems on the Russian space station. “In a last-resort move to free up the InSight Mars lander’s digging probe, NASA engineers programmed the lander to thwack itself with a shovel.” | learn more
tech, startups, internet ⚡
The founder’s guide to markets. Markets matter for startups, so founders should pick great ones! “Problem is, there are no clear frameworks to figure out what a great market is. Traditional advice is to target markets that are large and/or growing fast. That’s vague. So, what makes a great market? This is what we set out to answer.”| learn more
better doing 🎯
Yale’s “most popular class ever” is available for free online. It’s called The Science of Well-Being. The online ratings and feedback are impressive: 4,000+ ratings with 98% approval and 4.9 stars. Direct link to course. If you’re not quarantined with small children, you should have plenty of time to check it out! Let me know how you like it 😂. The learn more link is to a summary with some more detail. | learn more
to your health ⚕
New federal rules allow medical records on your smartphone. You technically have access to your records today, but not really in practice. “Officials said the rules likely will give patients a greater say in health care decisions and put an end to a long-standing practice in which some doctors and hospitals resist handing complete medical files over to patients upon demand.” Epic, the giant health records company, thinks giving you access is a bad idea. | learn more
What’s the point of a primary care doctor? “They seem to exist entirely to funnel patients to more expensive specialists — but it may be the consumer, not the healthcare industry, who’s really to blame for this, and we’re suffering as a result.” | learn more
retail therapy 💸
The direct-to-consumer playbook is a trap. “It goes without saying that I’m bearish on DNVBs as a whole. As a whole, the industry tends to rely upon left-brain operators with systems and definite plans. But, I’m bullish on the challenger brands who’ve figured out that winning is often a result of rewriting the playbook. For the brands looking to grow to (efficient) critical mass or even an exit, the DTC playbook is a trap.” | learn more
under the microscope 🔬
A new technique to remodel the gut microbiome. Peptides! “Instead of trying to kill harmful bacteria, or transplant beneficial bacteria, this hypothesis imagines remodeling, or reconstructing, a dysfunctional microbiome into a healthy one by using highly targeted peptides that can affect a broad number of different bacteria in very specific ways.” | learn more
A new rubber-like material to replace human tissue. The researchers think it could work well as a cartilage replacement for joints. “The results showed that the new rubber-like material may be appropriate for many applications that require an uncommon combination of properties—high elasticity, easy processability, and suitability for medical uses.” | learn more
thoughts of food 🍔
An edible blob filled with liquid. This is really cool! “The package, which is also compostable, is made from seaweed and plant extracts. You simply bite the corner off and drink.” | learn more
big ideas 📚
Lasers could (maybe) cut lifespan of nuclear waste to 30 minutes. This is still a crazy idea at this point. However, it’s being proposed by a physicist Nobel laureate. “We think that in 10 or 15 years’ time we will have something we can demonstrate.” Solving the nuclear waste problem would be a huge win for nuclear (renewable) energy. | learn more
on the blockchain ⛓
Fred Wilson’s buying more Bitcoin. When bad news hits, risk assets are sold off in a hurry. Then, investors and traders reevaluate and start thinking more critically about what to buy. Bitcoin sold off along with everything else, and now it’s starting to recover. Meanwhile, we’re inflating our currency like its going out of style. So…. | learn more
calls to action 👇
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