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P.S. You Should Know... | Issue #221

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June 20 · Issue #221 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fifth year!

my story 🚀
  1. I don’t know much about 5G. But, I read recently that the U.S. Department of Defense is investing billions into testing and application prototyping. The article’s point was not that they’re investing, but that the investments are already paying dividends. One example is a private and portable mesh network that can scale across 100 miles. Another is a “telemetry-driven mixed reality platform for drone operations.” Each of these new technologies are the product of people working at the boundaries of what’s possible in their fields.
  2. How many fields are there? The article above left me thinking about the rest of the innovation landscape. There are an estimated 30,000 scientific journals. There are many people advancing the limits of their fields right now.
  3. Maybe the next world-changing tech is already here. An example: It was way back in 2012 when CRISPR-Cas9 first came into the scientific literature and patent office (separately, causing drama). We’re still far from seeing the full impacts of the molecular scissors that can cut and paste DNA. Meanwhile, we’re learning that the genome itself is just the beginning. The epigenome regulates how and when our genes express, and there’s more to learn there. And this is just one field. It’s exciting to think that every day a researcher somewhere is on the verge of the next big breakthrough.
someone else's words 💬
fun facts 🙌
The shortest possible game of Monopoly. 21 Seconds. | learn more
Farewell, millennial lifestyle subsidy. “These companies’ investors didn’t set out to bankroll our decadence. They were just trying to get traction for their start-ups, all of which needed to attract customers quickly to establish a dominant market position, elbow out competitors and justify their soaring valuations. So they flooded these companies with cash, which often got passed on to users in the form of artificially low prices and generous incentives.” | learn more
How do Star Trek stardates work? “On Star Trek, we hear a lot of "stardates,” meant to mark some futuristic date. An example is stardate 47457.1, which is Captain Picard’s birthday… Let’s go deep-nerd on this.“ | learn more
oh, chicago 🏆
Illinois’ finances improved after Covid-19. While it’s technically true, don’t forget the $144 billion of unfunded pension liabilities. “Vendors are being paid at a faster pace than at any point in the past 20 years. And a $42 billion state budget soon headed to Democratic Gov. JB Pritzker fully funds big priorities, lacks some of the familiar accounting gimmicks of years past and appears balanced.” | learn more
tech, startups, internet ⚡
Jason Calacanis on 2021 startup valuations. “The market is scorching hot, with startups across all growth stages getting funded faster and at higher valuations.” | learn more
Why bioplatforms matter and can even save the world. By Avak Kahvejian, partner at the incubator behind Moderna: Flagship Pioneering. “This ability to understand, devise, manufacture, test and distribute antidotes and vaccines to a novel virus was due in large part to the development and maturation of bioplatforms.” | learn more
to your health ⚕
Underwriting life insurance with epigenetics. Coming soon: “At FOXO Technologies, we are committed to developing a new underwriting protocol based on the science of epigenetics.” | learn more
Dr. Peter Attia does a deep dive into blood glucose. “Additionally, Peter explains why he encourages all his patients, even nondiabetics, to utilize a continuous glucose monitor (CGM) which gives important insights that traditional lab testing and metrics consistently miss.” Related: NutriSense! | learn more
under the microscope 🔬
Parasite grants ants “eternal youth” – but there’s a dark side. “The parasites live in the ants’ guts, where they seem to bestow their hosts with much longer lifespans than uninfected ants.” | learn more
thoughts of food 🍔
The development of the fish stick. “The fish stick - the bane of schoolchildren who generally consider it an overcooked, bread-encrusted, cardboard-tasting, fish-less effort of lunchrooms and mothers to deceive them into consuming protein - is a postwar invention that came into existence as the confluence of several forces of modernity.” | learn more
on the blockchain ⛓
Iron Finance implodes after ‘bank run’. “In a month, Iron Finance has gone from being the darling of yield farmers to one of the biggest crashes in DeFi history.” | learn more
Maren Altman is TikTok’s wildly popular cryptocurrency astrologer. “Her most intriguing videos apply astrology to a particularly daunting realm: cryptocurrency. Anything with a verifiable birthday or creation date has a birth chart that can be read and, according to astrologers, gleaned for predictive information.” | learn more
Untraceable Bitcoin is a myth. Last week’s link mused on exactly how the government recovered some of the Colonial Pipeline ransom. This week, Ezra Galston from Starting Line added additional perspective in the WSJ. “Bitcoin is anonymous, but it’s far from private—an important but often overlooked distinction. The Justice Department recovered more than $1 billion in bitcoin in various investigations during 2020 alone.” | learn more
profiles of people 🚶
$110 million helmet aims to unlock brain’s secrets. This profile of Braintree founder Bryan Johnson is interesting for two reasons. First, he’s managed to reverse his biological age to be a decade younger than his actual age (you’ll believe it when you see his photo). Second, his company is, “building hardware meant to radically expand science’s understanding of the brain’s aging and effects on the body.” | learn more
Meet All Elite Wrestling’s Tony Khan. “With AEW, the 38-year-old CEO has built the first real threat to Vince McMahon’s WWE in more than two decades. Inside the billionaire vs. billionaire smackdown.” | learn more
calls to action 👇
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