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P.S. You Should Know... | Issue #228

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August 8 · Issue #228 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fifth year!

my story 🚀
Thanks to Red Bull for giving us wings (and Lolla tickets)!
Thanks to Red Bull for giving us wings (and Lolla tickets)!
I don’t publicly thank Kim often enough for creating the space for me to publish this newsletter for 228 weeks in a row through pregnancies, parenting, pandemics and more. Thank you, Kim! If you enjoy this newsletter, consider reaching out to thank her as well :).
fun facts 🙌
Support from loved ones: sometimes helpful. “The scholars had entirely expected that having a supportive partner there would diminish the stress of giving a speech. And that did happen for the men; having their girlfriend or wife there calmed them considerably. But to the researchers’ surprise, it was the exact opposite for the women.” | learn more
The AI wolf that preferred suicide over eating sheep. “The game was simple. Two wolves and six sheep would be placed at random within a game space by the computer. The wolves would have to catch all the sheep in 20 seconds while avoiding some boulders within the space.” | learn more
The insecurity industry. By Edward Snowden: “The greatest danger to national security has become the companies that claim to protect it.” | learn more
oh, chicago 🏆
Another set of winners in Illinois’ dispensary license lotteries. “Eight licenses so far have gone to this address at Chicago’s 4880 N. Clark Street, a location once used as an office for D33 Dispensary’s owners.” | learn more
tech, startups, internet ⚡
CEO fires 150 after AI analysis told him to. “You received this email because my big data team analyzed your activities in Jira, Confluence, Gmail, chats, documents, dashboards and tagged you as unengaged and unproductive employees.” | learn more
Advertising stagflation. “I think I’ve finally found one part of the economy where I’m already seeing a kind of stagflationary dynamic play out—Facebook ads.” | learn more
How fast is too fast? “Is the pace of today’s fundraising environment actually in the best interest of founders?” | learn more
better doing 🎯
How to conduct investment research. This applies to publicly traded companies. I really like it! “I’ve spent thousands of hours researching dozens of companies from many different industries. Along the way, I’ve developed a research process. While I’m no expert, I’m hoping that this article – which outlines my process – will be valuable to other students of investing.” | learn more
to your health ⚕
DMT: the strongest psychedelic you’ve never heard of. “Early reports from Small Pharma suggest that DMT, in conjunction with therapy, can be used to help break away from undesired behavioral patterns. Other studies also suggest that it could prove useful in helping with depression and anxiety.” | learn more
under the microscope 🔬
Obesity doesn’t always mean ill health. Shockingly interesting! “Many researchers and doctors—and broader societies—take it as a given that obesity means ill health. In fact, says Ruth Loos, who studies the genetics of obesity at the University of Copenhagen, “We can be obese but remain healthy.” Scherer, Loos, and other researchers worldwide are examining genes, animal models, and humans to understand how factors such as the distribution of fat in the body and the nature of fat itself can blunt or compound any health impacts of extra weight.” | learn more
Can a blood test reveal the time on the body’s internal clock? “Studies are starting to demonstrate how one day we might be able to check the time of this body clock through a simple blood test, and a team at the University of Colorado (CU) Boulder has now put forward a new technique that proved highly accurate alongside the current gold-standard approach.” | learn more
big ideas 📚
On Medici and Thiel. “A few hundred years ago, Cosimo Medici kickstarted a financial empire. At that same time he began a grand tradition of patronage, of Donatello most notably.” His kids provided patronage to Leonardo Da Vinci and Michelangelo. Where have all the patrons gone? Is Peter Thiel’s Fellowship the closest analog today? | learn more
on the blockchain ⛓
A $100k prize for a decentralized inflation dashboard. “If inflation is a government-caused problem, we can’t necessarily rely on government statistics like the CPI to diagnose it or remediate it. Indeed, in places with high inflation, censorship and denial is the rule rather than the exception.” | learn more
Ethereum transactions are reasonably priced again. The ‘London’ hard fork happened this week and a transaction on the blockchain no longer costs as much as an international wire transfer. Let’s hope this lasts! | learn more
calls to action 👇
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