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P.S. You Should Know... | Issue #239

October 24 · Issue #239 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fifth year!

my story 🚀
Petra and I showed our friend our favorite view of Austin by water. 🛶
Petra and I showed our friend our favorite view of Austin by water. 🛶
someone else's words 💬
fun facts 🙌
NASA chief Bill Nelson talks UFOs. It’s a big universe out there. | learn more
The history of the Henley shirt. “Since 1839, the town of Henley had been the home of the Royal Regatta, the largest rowing race in all of England.” | learn more
Re: ‘cuts’ in the treads in the tops of plastic soda bottles. It never fails to impress me how one can learn by sending emails to the right folks. “I didn’t know the answer to this one, so I sent an e-mail to Alcoa’s Closure division (I figured that Alcoa knows about anything associated with aluminum, including lids).” | learn more
oh, chicago 🏆
Vienna Beef’s Top Dog. “[Stephanie] Esposito, of the Southwest Side, visited 367 hot dog stands in just five weeks to win Vienna Beef’s Hot Dog Stand Challenge. The second- and third-place winners — sisters Karen Buralli and Rose Lamont — also ate at all 367 participating stands, but they finished in six weeks.” | learn more
tech, startups, internet ⚡
So…I bought a bank. This is a wonderful example of “do things, tell people.” Brian Barnes, CEO of Chicago-based M1 Finance, bought a bank and wrote about it. Of interest, it seems he bought the bank personally because, M1 “has work to do before it’s ready to become a bank holding company.” | learn more
Rethinking language learning, beyond the game-like apps. An interview with Toucan founder Taylor Nieman. “Toucan launched a year ago on Product Hunt, in September 2020, and it was very well received. They were the #1 product on the day.” | learn more
Zillow doesn’t want to buy houses anymore. Zillow’s been in the house-flipping business since 2019. After buying 3,805 homes in Q2 of this year, they are pumping the brakes. Why? They are struggling with labor, materials, and a competitive real estate market. | learn more
to your health ⚕
How overnight fasting could extend lifespan. Intermittent fasting shows health and longevity benefits in a variety of species. This short article published in Nature highlights a study that’s also linked fasting results to the circadian clock. | learn more
retail therapy 💸
Flexport’s founder rented a boat to tour the port of LA. You know that problem that’s cascading throughout the country? Yeah, the supply chain problem. The port’s cranes aren’t the bottleneck; it’s container storage. | learn more
Home Depot + Walmart for faster shipping. I think this was only a matter of time. Redundant logistics networks are really expensive. “The Home Depot is the first retail client of Walmart GoLocal, which uses Walmart’s expansive network to deliver products for businesses of all sizes.” | learn more
Is shoplifting forcing Walgreens to cut back in S.F.? The company blames rampant retail theft for the store closings. A 2014 California law classified shoplifting < $950 as a misdemeanor, possibly leading to fewer reports and less enforcement. Critics say they’re just using shoplifting as convenient cover for stores they intended to close anyway. | learn more
under the microscope 🔬
Space travel and senolytics. Senolytics are the class of drugs that target senescent cells (so-called “zombie cells”). While the basis for using these drugs to delay, prevent or reverse aging is still limited, there’s certainly a lot of excitement in the field. Also, there’s a link to space travel! Solar flares in space cause a lot of cells to turn senescent, so NASA is interested in working out a solution. It might be necessary for long voyages, like to Mars. | learn more
Strategies for targeting senescent cells in human disease. This paper was recently published in Nature Aging. “Here we review features of senescent cells and strategies for targeting them, including immunologic approaches, as well as key intracellular signaling pathways. Additionally, we survey current senolytic therapies in human trials.” | learn more
thoughts of food 🍔
No more than 200 feet away from food. “This snack curator for Google is one of the most powerful people in food.” | learn more
Illegal sprinkles force British bakery to shelve popular cookies. “A slice of the 12-layer chocolate cake known as "Bruce” is adorned with colorful sprinkles at the British bakery Get Baked. But regulators say the topping is illegal, as it includes a color additive that is permitted only for other uses.“ | learn more
on the blockchain ⛓
Venture fund 1confirmation’s OpenSea investment memo from 2018. The marketplace recorded $3.4 billion in transaction volume this August, up 10x from the month before. | learn more
Why crypto is a lot different today than in 2017. Way back then, every project was a concept full of hypothetical revenue earned at the protocol level and accrued to the token holders. Today there are multiple projects that generate protocol revenue. This is still not quite “solid ground” for crypto, as most of that revenue is coming from either interest or trading fees, which are both driven by the vast speculative environment we’re in. | learn more
calls to action 👇
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