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P.S. You Should Know... | Issue #252

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January 23 · Issue #252 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fifth year!

my story 🚀
fun facts 🙌
Predictions of 2022 from a hundred years ago. Published by W. L. George in the New York Herald in 1922, many of the predictions hold up surprisingly well. | learn more
Who was Tarrare? This story is incredible. “[A] French showman and soldier, noted for his unusual appetite and eating habits… He was hospitalised due to exhaustion and became the subject of a series of medical experiments to test his eating capacity, in which, among other things, he ate a meal intended for 15 people in a single sitting…” | learn more
The zen of drinking alone. “Use alcohol to find your inner monkey.” | learn more
oh, austin 🤠
Austin’s record real estate stats for 2021. “The Austin-Round Rock MSA saw 41,316 homes sold in 2021, 2.5% more than a record-setting 2020. Median home prices skyrocketed as well, rising 30.8% from 2020 to $450,000.” | learn more
tech, startups, internet ⚡
The poor ROI of truck autonomy. A detailed and easy-to-grasp economic analysis of trucking automation from the CEO of Starsky. “The hardest 1% of the technical problem, automating the surface streets and interchanges, would end up being worth only about $600/truck/yr. Level 4 truck autonomy has less value than a daily coffee.” | learn more
When we design our identities from scratch. Sarah Guo thinks pseudonymity will help us all use the internet better. I’m seeing more pseudonymous writers building names for themselves lately. Without any credentialing they manage to build brands and audiences based solely on merit. | learn more
better doing 🎯
Managing todo lists with pen and paper. My current system is avoiding todo lists in favor of calendar events for things I need to do. This is an interesting perspective on the psychology behind these lists. “The biggest hurdle todo faces is that the emotion you generally experience when you look at your todo list is shame.” | learn more
to your health ⚕
The Mark Cuban Cost Plus Drugs Company. “The business plan is supply chain transparency: buying drugs from wholesalers, packaging them, adding a 15% markup and selling to pharmacies, clinics and health systems. The goal, according to the website, is to produce “low-cost versions of high-cost generic drugs.”” | learn more
3 bold predictions about the consumer health & wellness industry. From Jess Schram, an MBA candidate at Columbia Business School. “(1) people are increasingly opting out of insurance coverage, (2) what insurance companies of the future will need to look like to stay alive, and (3) how adjacent consumer industries such as CPG, fitness, mobile apps, alcohol/spirits, and others will follow-suit to cater to an increasingly health-conscious population.” | learn more
Describing a medically supervised ketamine journey. In a follow-up to a post from October where he described a visit to Nashuma’s Psychedelic Wellness Center, Daniel Zahler went back and actually tried the product. “I surrendered to the experience. For the next 60 minutes, I closed my eyes and let myself float along a journey into the recesses of my mind.” | learn more
retail therapy 💸
The inside story of Facebook Marketplace. The inside story of Facebook Marketplace, as told by Deb Liu. She led the team that pitched, built, launched and scaled the world’s second-largest marketplace. It’s also my favorite place to sell random items like my old Apple TVs. | learn more
under the microscope 🔬
Discovery of amyloid hairpin structure hints at vaccine for Alzheimer’s. “A new study has uncovered a previously unknown hairpin-like structure within this protein that proved critical to an antibody response seen in mice, with an engineered version of the protein fragment also laying the groundwork for a vaccine against the disease in humans.” | learn more
big ideas 📚
What is actually a heretical view? It’s interesting to consider that most heretical views are only partially so. Tyler Cowen offers these categories: 1. Used to be heretical, or on the verge of switching. 2. It’s heretical to say but the actual idea is not heretical. 3. The idea is not heretical globally. 4. Popular views, but heretical with many elites.“ | learn more
Emergence: A unifying theme for 21st century science. “When electrons or atoms or individuals or societies interact with one another or their environment, the collective behavior of the whole is different from that of its parts. We call this resulting behavior emergent. Emergence thus refers to collective phenomena or behaviors in complex adaptive systems that are not present in their individual parts.” | learn more
on the blockchain ⛓
The hidden hand marketplace. A crypto group has developed a marketplace for organizing vote-buying in governance tokens. Why is this interesting? Well, consider how important vote-buying was to governance of cities and states in the US a hundred or so years ago. | learn more
A DAO bought a copy of Dune for $3 million thinking it was the copyright. New crypto technology allows people to organize in new ways. But it doesn’t prevent them amplifying dumb ideas and poor diligence in new ways. | learn more
calls to action 👇
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