P.S. You Should Know... | Issue #260

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March 20 · Issue #260 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its fifth sixth year!

my story 🚀
Happy Purim! Despite the lack of smiles in the photo, the girls loved drumming. 🥁
Happy Purim! Despite the lack of smiles in the photo, the girls loved drumming. 🥁
Today is the five year anniversary of P.S. You Should Know! When I set out to create a space to share interesting ideas, I had no idea that it’d become a mainstay in my life every single week for the next 5 years (and counting). I am so glad that it has, and that you’ve opted to join me each week. Here’s a throwback link to the first issue.
fun facts 🙌
Behind each plastic bottle cap is a careful engineering process. Heinz Ketchup, Sriracha, and Vita Coco have very innovative caps. “Let’s take a look at what goes into a few of these mechanical marvels with the help of our industrial CT scanner.” | learn more
Typography is impossible. “The practical guide to why laying out type never quite does what you want.” | learn more
How much gold is there in the world? A five minute video. Did you know that 90% of recycled gold currently comes from jewelry? | learn more
oh, chicago 🏆
A new lion roars into town. “A cub was born at the [Lincoln Park] zoo Tuesday, marking the first time an African lion cub has been born there in 20 years, according to a zoo news release.” | learn more
tech, startups, internet ⚡
How on earth I became an entrepreneur. “I was first alerted of my uselessness in 1995, when ~ fresh out of college ~ I worked as an intern at the Mayor’s Office of Film, Theatre & Broadcasting in New York City.” | learn more
DNA synthesis at scale. This interview with Emily Leproust, co-founder and CEO of Twist Bioscience, is part personal bio, part founding story, and part glimpse into the future of a bio-based economy. I came away impressed by her as a businessperson and leader! | learn more
Venture capital returns are very skewed. “In those posts I was analyzing data from Correlation Ventures that showed … that 65% of investment rounds fail to return 1x capital and only 4% return greater than 10x capital.” | learn more
better doing 🎯
Joining hypergrowth startups. “The advice is meant for anyone joining the early stages of a hypergrowth team (15-150 people; multiplying in revenue, investments and/or headcount). Usually in the first 1-3 years of a startup. Most of the advice I would not give in larger, more established teams. I also did not try to sugarcoat nor glorify things.” | learn more
Five ways to grow through SEO that are not content marketing. “Yes, we all know that when it comes to Search, original content is king. But there are multiple effective ways to generate quality and original SEO traffic. And some of those ways don’t require writing a single article.” | learn more
CMO secrets revealed. “13 marketing leaders share secrets that will change how you market today.” Okay that headline might oversell it, but this is educational anyway. | learn more
retail therapy 💸
How to import duty-free with Section 321. Some of your favorite direct-to-consumer clothing brands use this loophole to import Chinese-made products without any tariffs. | learn more
under the microscope 🔬
Polygenic screening of embryos is here. “The first child born using the technique arrived last year. But can it really help reduce diseases in a new generation, or is it ‘techno-eugenics’?” | learn more
Pulse as a biometric measure of wellbeing. “Pulse rates have been overlooked as a potentially valuable way of capturing individuals’ wellbeing. The value of pulse rate as a wellbeing metric is that, unlike subjective wellbeing metrics, it is recorded on an objective cardinal scale.” | learn more
Applying mRNA to healing broken bones. “Overall, the Mayo Clinic team argues that in bone healing, mRNA “promises to couple affordability with efficacy, and clinical expediency with safety, while presenting fewer barriers than traditional gene therapy to clinical translation.” | learn more
big ideas 📚
Ark Invest’s big ideas 2022. “This annual research report seeks to highlight our most provocative research conclusions for the coming year.” Multi-omics, autonomous ride-hail and logistics, and orbital aerospace all sound pretty interesting to me. | learn more
calls to action 👇
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