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P.S. You Should Know... | Issue #263

April 10 · Issue #263 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its sixth year!

my story 🚀
Daphne does airport lounges like a pro, and with healthy food choices! 🥦✈
Daphne does airport lounges like a pro, and with healthy food choices! 🥦✈
fun facts 🙌
Walmart owns most of the supermarkets in Mexico. Also, on a per capita basis, there are more Walmart-owned stores in Mexico than the US. | learn more
America in 1950: U.S. releases detailed census data after 72-year waiting period. “What makes the 1950 Census so significant is that it’s the first one that details an America on the heels of World War II, at the start of the baby boom and in full postwar economic swing a decade after the Great Depression.” | learn more
Why is flaking so widespread in San Francisco? Having never lived in SF, I have little direct experience with this problem. This makes me feel quite grateful for my midwestern cultural upbringing. | learn more
tech, startups, internet ⚡
TV, merchant media and the unbundling of advertising. From Benedict Evans. “Amazon’s ad business is bigger than YouTube and more profitable than AWS. Shein is the biggest fast-fashion retailer in the US, with no stores. US pay TV subscribers have fallen by a third. Where do ad budgets go, where does rent go, and how many brands will there be?” | learn more
What percentage of AngelList seed-stage startups become unicorns? Beware of selection bias here, even when it’s not obvious (i.e. the last decade might be unique). “We analyzed over 2,600 seed-stage startup investments made on AngelList dating back to 2013 to determine the likelihood of any startup achieving unicorn status today.” | learn more
better doing 🎯
95th percentile isn’t that good. “Reaching 95%-ile isn’t very impressive because it’s not that hard to do. I think this is one of my most ridiculable ideas. It doesn’t help that, when stated nakedly, that sounds elitist. But I think it’s just the opposite: most people can become (relatively) good at most things.” | learn more
to your health ⚕
Modifying your diet may help you manage spring allergies. Bring on that local honey! | learn more
retail therapy 💸
Amazon’s grocery business has become an ‘expensive hobby’. “Amazon has introduced a dizzying array of services — Prime Now, Fresh, Go and others — in its effort to become a giant in the $750 billion U.S. grocery market. In 2017, it spent $13.7 billion to acquire Whole Foods, a price tag more than 10 times higher than Amazon had paid in any prior deal. Still, it’s just a niche player in the industry.” | learn more
under the microscope 🔬
The genetics of immunity. “This wave of studies has identified many new genetic associations with disease—but it has also produced a confusing phenomenon: the majority of GWAS variants are located in non-coding regions of the genome. That is, we went out in search of the relationship between our genetic instructions (genes) and traits, and found the answers to be outside of the instruction set (the coding regions of genes).” | learn more
Background on brain-reading news from last week. I had shared an article about a man who communicated in full sentences using nothing but thought (a first-ever). At that time, I didn’t realize the interesting background about the researcher – his prior brain-reading research had been discredited and his article retracted from PLOS Biology. | learn more
Top entrepreneurial bio labs in the US. “I have identified 160+ translational labs that already have started or might likely start a company based on their research. These bio labs are in the top clusters (Bay Area, San Diego, New York, Massachusetts, Connecticut, and newly New Jersey and LA).” | learn more
big ideas 📚
Why U.S. population growth is collapsing. “Journalists are obsessed with the question of why Americans aren’t having more babies…. But it’s the other two factors—death and immigration—that are overwhelmingly responsible for the collapse in U.S. population growth.” Please give us more immigrants! | learn more
Why SpaceX is an underrated strategic national asset for the U.S. “The U.S. needs more moonshot projects like SpaceX—both literally and figuratively. The federal government can play an important role as a buyer-of-first-resort in industries that offer public goods.” | learn more
on the blockchain ⛓
If Wolf of Wallstreet were about crypto…
joma 🤏
if Wolf of Wallstreet were about crypto...
calls to action 👇
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