P.S. You Should Know... | Issue #270

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May 29 · Issue #270 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its sixth year!

my story 🚀
Italian night with the girls. 🍝
Italian night with the girls. 🍝
  1. Our summer travels start soon. We’ll be spending most of June in Chicago. I am grateful we get to have an extended visit near family and friends. I’m also excited to get out there and enjoy the best of Chicago summer. If you have any suggestions on new restaurants or things to do let me know!
fun facts 🙌
Everything in the universe is vibrations. Less than a minute and very neat. | watch video
When buying the dip doesn’t work: an analysis of the dot-com crash. I was not old enough to pay attention to the first tech bubble. This is an elegant analysis. “And, if you are a super dip buyer and bought after things fell -70%, you would still have to wait 2.5 years to recover and stomach a -42% drop.” | learn more
oh, chicago 🏆
The parking meter deal that keeps on taking. “Parking meter revenues are nearly back to pre-pandemic levels. With 61 years to go on the 75-year lease, Chicago Parking Meters LLC has now recouped its entire $1.16 billion investment, plus $502.5 million more.” | learn more
tech, startups, internet ⚡
Artificial intelligence is breaking patent law. “Patent law is based on the assumption that inventors are human; it currently struggles to deal with an inventor that is a machine. Courts around the world are wrestling with this problem now as patent applications naming an AI system as the inventor have been lodged in more than 100 countries.” | learn more
Startups and the creator economy winter. “TL;DR Because 99% of creator revenue accumulates at the top .01% of creators, creator economy startups have to find a way to justify taking a % of revenue. This is not an easy task and only a select few will succeed in the coming bear market.” | learn more
better doing 🎯
Think about systems more than goals. “Goals are important insomuch as you need to decide where you want to go. Only, too often, entrepreneurs spend their valuable time thinking through goals only to have them sit on the side in a dormant state. Once there’s a general direction, effort is much better spent on the systems and processes that will culminate in achieving the goals.” | learn more
Thoughts on OKRs. “For OKRs, here are the failure modes I saw repeatedly, and took part in.” | learn more
to your health ⚕
Data from wearable devices are changing disease surveillance. At an individual level, wearables can offer a unique insight into your body’s performance. Mine is eerily good at predicting if I’m getting sick. At a population level, there’s even more to learn. | learn more
retail therapy 💸
So you want to launch a physical product. I am sure many of us have had that “I can make this better” thought cross our minds before. This is a brief guide for those who want to act on it. “Brilliant product ideas don’t fall from the sky fully-formed. The best ideas start with a ripe audience and a unique observation, and take it from there.” | learn more
under the microscope 🔬
When fed plasmalogens, aged mice perform more like young mice. “The effects of the plasmalogen supplement on learning and memory were tested by training mice to use a Morris water maze — a pool of water that contains a platform that serves as a resting area.” | learn more
Microbiota-brain axis: context and causality. “Most evidence linking the gut microbiota to brain phenotypes and behaviors is from animal models. These preclinical studies have informed strategies for further analyses and interventions in humans, but more rigorous human studies are needed to distinguish causality from association.” | learn more
Artificial intelligence predicts patients’ race from their medical images. One interesting element here is that the researchers can’t figure out how this works. They even tried obscuring things they thought were indicators like bone density, but that didn’t stop the AI. | learn more
thoughts of food 🍔
The pizza lab: why does pepperoni curl? This is a delightfully thorough lesson in pepperoni. “I’m talking about pepperoni curl. What it is, what makes it happen, and how to maximize it.” | learn more
on the blockchain ⛓
I had Total Value Locked (TVL) all wrong. I was explaining this to a friend recently as “the sum of the token values locked in smart contracts, at the time it was locked.” After I said it, I decided I wanted to find a good article. It turns out I had a very naïve understanding of this oft-used metric. Now I’m not sure I really understand it at all. | learn more, and more, and more
‘Move-to-earn’ Solana app StepN is latest crypto gaming craze. “Indeed, the fast-growing app appears to be self-sustainable for now. It’s generating $3 million-$5 million in net profit from trading fees a day and earning up to $100 million every month. … Some argue what makes StepN — and other play-to-earn blockchain games like Axie Infinity — successful is the fact that they are essentially financial products with a gamified twist.” | learn more
calls to action 👇
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