P.S. You Should Know... | Issue #294





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November 13 · Issue #294 · View online
P.S. You Should Know...
👋 Welcome back to P.S. You Should Know… probably the best newsletter published on Sundays between 6-7am CST, and definitely the best one published by me. Now in its sixth year!

my story 🚀
We celebrated Daphne's 3rd birthday this week!
We celebrated Daphne's 3rd birthday this week!
fun facts 🙌
Happy Gilmore’s alligators. “Real and fake alligators were used in the film as well as a frog which is seen briefly sitting on a tree limb at a golf course. Two live alligators were transported from California to Vancouver, British Columbia. … One of the alligators named McNasty, was chosen because she has a particularly wild temperament.” | learn more
Why did it take so long to invest the thermometer? Since the third century BC, the “inverted flask experiment” demonstrated the basic mechanics of air temperature impacting the water level in a column. But it wasn’t until the 1600s that someone paired it with a scale to turn it into a measurement tool. The implication? There are plenty of low-hanging fruit inventions still out there, waiting to be discovered. | learn more
The guy who inspired “quiet quitting” is back to working 50 hours a week. “In March, [the reporter] profiled a recruiter, using the pseudonym Justin, who slowly cut back the hours he devoted to his job without much consequence. … In her latest column, Ito caught up with Justin six months later, and found the vibes had shifted…” | learn more
tech, startups, internet ⚡
The bubble has popped for unprofitable software companies. Basecamp cofounder takes a bite out of his unprofitable competitors in this recent blog post. “The venture capitalists who invested in Asana, Monday.com, and Smartsheet surely all made out like bandits when these unprofitable software companies went public. Now every single one of these stocks is getting destroyed in the public market, as investors sour on the idea of them losing hundreds of millions of dollars every year chasing growth with no prospect of profits in sight.” | learn more
Will startups or incumbents capture the value of AI? Elad Gil: “Every tech wave results in a different split of startup vs incumbent value.” | learn more
Losing a month of runway to inflation. “In the mid-2000s, many startups invested their excess cash reserves in instruments called Auction Rate Securities. ARS produced a steady stream of interest payments, like savings accounts, with a higher return.” It seemed great, until it wasn’t anymore. | learn more
to your health ⚕
FDA deregulation increases safety and innovation and reduces prices. “Deregulated device types show increases in entry, innovation, as measured by patents and patent quality, and decreases in prices. Safety is either negligibly affected or, in the case of products that come under potential litigation, increased.” | learn more
First-ever gut health test for expecting parents and infants. Congratulations, Cheryl! “[Her] mission was to give parents a head start in preventing gut imbalances in their babies’ critical first 1,000 days of gut development, during which eczema, allergies, asthma, obesity and other chronic diseases may form.” | learn more
under the microscope 🔬
Microneedle patch digs deep to regenerate hair in bald mice. “The device works by tackling oxidative stress that impacts on follicles, with the result being thicker and denser hair coverage than what is possible through commonly used treatments.” | learn more
A decades-long quest pairs an e-nose with a brain implant. “For people who have lost their sense of smell, a neuroprosthetic could replace biology with technology. An e-nose sensor would detect odors, a processor would send signals to an implanted receiver, and an implanted electrode array would stimulate the olfactory bulb with patterns corresponding to specific odors.” | learn more
thoughts of food 🍔
NIH-funded “Food Pyramid” rates Lucky Charms healthier than steak. “A few weeks ago the White House hosted a conference on hunger, nutrition and health. One of the key organizers of the conference — Dariush Mozaffarian, Dean of the Tufts School of Nutrition — had just finished spending 3 years and millions of dollars designing a new food pyramid. His findings? Lucky Charms are healthier than steak.” | learn more
teaching the kids 👩‍🏫
On aristocratic tutoring. The language is casual, but the ideas and reasoning are sharp. “It’s no secret that school sux. It’s not that tutoring is good, it’s that mechanized schooling is really bad. If we got rid of formal 20th century K-12 education, and did homeschooling / unschooling / let kids work at the costco, we would get most of the benefits of tutoring without all the overhead and inequality.” | learn more
big ideas 📚
Atoms are local. I can’t do justice to this article with a summary. If you only read one this week, let this be it. It explores this idea: “how do we get to a future where everything grows on trees?” | learn more
on the blockchain ⛓
Whoa, FTX. I don’t have a link to share about the FTX drama. But I can’t help mentioning it. My short summary: the second largest crypto exchange has suddenly collapsed, and of course it’s because of fraud and leverage. Not only does the whole situation smell of Enron, but the CEO they brought into sort out the mess is the same guy who cleaned up the Enron mess twenty years ago.
Blockchain guy sets Frida Kahlo drawing on fire. It was estimated to be worth $10 million. He did it to mint 10,000 NFTs. He only sold 4. | learn more
calls to action 👇
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